The ideal attributes of a drug delivery system for biologics must combine the ability to effectively provide therapeutic doses of unmodified proteins with safety. There are multiple requirements for use in all organs. TheraKine's system has these properties:
- The ability to be fully resorbable
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No acid burst or other unsafe excipients or byproducts
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Concentration equivalence of over 100 mg/ml
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pH to be physiological (7.0 to 7.8 pH)
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280 to 360 mOsmol/l
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Release kinetics controlled for up to 6 months
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The ability to provide an initial bolus or fully linear release
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The ability to be injected as a clear or colored gel
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The ability to be injected as a pellet or rod
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The capability to work with all classes of large molecule biologics
- The ability to have either hydrophobic or hydrophilic bolus formulation
The system has been verified using a number of commercially available biologics and in studies with several biopharma companies.